The Essential Guide to Mescaline

The Third Wave:

Mescaline is the primary psychoactive alkaloid in a range of psychedelic cacti, including peyote (Lophophora williamsii), San Pedro (Echinopsis pachanoi), and Peruvian torch (Echinopsis peruviana)—all of which are native to the southwestern United States and northern Mexico. It can also be found in trace amounts in other regional plants, such as the Berlandier acacia (Senegalia berlandieri).

In its natural state, mescaline has been used for thousands of years in Native American religious ceremonies. It was also the first psychedelic to enter mainstream Western culture, predating the widespread use of LSD and psilocybin. More recently, the extracted compound has shown promise in the medical and psychotherapeutic treatment of substance abuse and depression among other conditions.

Pure mescaline is usually available as a white or brownish crystalline powder, either loose or packed into capsules. It can also be found as a liquid solution or brew. Compared to many other psychedelics, however, extracted mescaline tends to be rare in most parts of the world.

The fine folks at The Third Wave have put together a wonderfully thorough guide that covers this remarkable naturally-occuring psychoactive alkaloid.


This Week in Psychedelics - 6.8.18

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Cannabis

  • All eyes on Canada as first G7 nation prepares to make marijuana legal (The Guardian)
  • Bipartisan Legislation Introduced To Protect States That Have Legalized Marijuana (NORML)
  • 65 percent of Americans say it’s ‘morally acceptable’ to smoke pot (The Washington Post)
  • Study: Majority Of Chronic Pain Patients Replace Opioids With Cannabis (NORML)
  • Legalising cannabis ‘could earn Treasury £3.5bn’ (The Guardian)
  • Republican Rules Committee Blocks Veterans Medical Cannabis Amendments (NORML)
  • Banned from Wall Street, US cannabis companies go north (CNN)
  • Looking For Big Returns In The Cannabis Market? Look East, Not West (Forbes)
  • Virginia: Crime Data Shows Surge In Marijuana Arrests (NORML)
  • Colorado's Governor, Who Founded a Brewpub, Nixes Cannabis 'Tasting Rooms' (Reason)
  • Some California hospitals report uptick in ER visits for cannabis (Daily Democrat)
  • Part 3, The Most Common Qualifying Conditions for MMJ (Leafly)
  • L.A. Supervisors Support Bill to Automatically Expunge Some Cannabis Convictions (LA Weekly)
  • Portland Has Nearly Twice as Many Pot Shops as Liquor Stores (Willamette Week)
  • Watch This: Celebrities Keep Educating Conan About Cannabis (Leafly)
  • It's The 1st Day Cannabis Licenses In Mass. Can Be Issued, But Expect A Slow Rollout (New England Public Radio)
  • Why we must legalise cannabis now for the sake of public health (The Guardian)
  • A Dietitian's Surprising Take on Cannabis Edibles (U.S. News & World Report)
  • The Ontario Election: What Does It Mean For Cannabis? (Leafly)
  • NORML's Jared Polis Endorsement and Growing Power of Marijuana Voters (Westword)
  • High time India, the land of bhang, legalises marijuana: Shashi Tharoor (ThePrint)
  • Everything you wanted to know about cannabis legalization … but forgot to ask (The Guardian)
  • Why we need better, smarter, panic-free education on cannabis (The Conversation)
  • These Are The 4 Big Buzzwords in the Cannabis Industry Right Now (Entrepreneur)
  • The Cannabis Strains of Summer (for Every Tolerance Level) (East Bay Express)
  • California’s First Cannabis Business Owners Policy Approved (Insurance Journal)
  • Medical cannabis and the challenge for regulation of medicines (The Conversation)
  • Cannabis industry leaders opine on budding business (Bristol Herald Courier)

LSD

  • The political significance of LSD (Open Democracy)
  • ‘Largest ever LSD haul in Germany’ seized in Rhineland-Palatinate (The Local)
  • Sheriff: Wrong-way driver on LSD thought he was in video game 'Grand Theft Auto' (KVAL)

Psilocybin/Magic Mushrooms

  • California won't vote on psilocybin this year. Denver still might. (Rooster)
  • What Ever Happened to Denver's Magic Mushroom Initiative? (Westword)
  • When A Maryland Man Posted Pictures Of Morel Mushroom On Facebook, The Cops Showed Up (Inquisitr)
  • What It’s Like to Trip on the Most Potent Magic Mushroom (The Atlantic)
  • Psychedelic Medicine 101: Psilocybin and the magic of mushrooms (New Atlas)

MDMA/Ecstasy

  • Yours for £2: artist Chemical X donates ‘ecstasy’ work as prize for drug test charity (The Guardian)
  • Festival goers warned of high dose batches of ecstasy following deaths in UK (Independent.ie)
  • MDMA-Assisted Psychotherapy Mitigates PTSD Symptoms (Medscape)

Ayahuasca/DMT/5-MeO-DMT

  • Is it Cultural Appropriation for White People to Drink Ayahuasca? (Kahpi)
  • Spiritual exploration is the top reason people consume 5-MeO-DMT, study finds (PsyPost)
  • A Shamanic View of How Ayahuasca & Nature Communicate With Us (Kahpi)
  • Psychedelic tourism thrives in Peru despite recent killing (San Francisco Chronicle)
  • Ayahuasca Pilot Study Investigates the Meaning of Life and Death: Interview with Brad Adams, Ph.D. (Psychedelic Times)

Peyote/San Pedro/Mescaline

Synthetic Cannabinoids/Psychoactive Research Chemicals

  • Synthetic Weed Is Back, Bigger Than Ever, and Scary as Hell (The Daily Beast)

Dissociatives

  • From Chaos To Calm: A Life Changed By Ketamine (WMOT)
  • NPR (yet again) writes uncritically about ketamine for mental illness (Health News Review)
  • Guidelines for Use of IV Ketamine Infusions for Acute Pain Management Released  (MD Magazine)

Opiates/Opioids

  • High Schoolers Who Use Heroin Commonly Use Multiple Other Drugs (NYU News)
  • Naloxone Recalled Due To Particulate Matter (CBS Pittsburgh)
  • A new study shows stigma is hurting our response to the opioid epidemic (Vox)
  • She Went to Jail for a Drug Relapse. Tough Love or Too Harsh? (The New York Times)
  • Suggested Paths to Fixing the Opioid Crisis (JAMA Network)
  • U.S. Hunger For Opioid Alternative Drives Boom in Borneo Jungle (Bloomberg)
  • This Is Your Hand on Opioids: Trump's 'Very Bad Commercials' Rely on Dishonest and Pernicious Scare Tactics (Reason)
  • She paid nothing for opioid painkillers. Her addiction treatment costs more than $200 a month. (Vox)
  • Farmers tell govt to lift ban on cultivation of opium (The Tribune)

Absinthe

  • Absinthe Market will touch a new level in upcoming year – Key Players involved in the research (The Financial)

Kratom

  • 6 Most Common Myths About Kratom (Kratom Guides)
  • Kratom advocates fight FDA crackdown (Washington Examiner)
  • Buying Kratom In Canada? Is that Kratom legal In Canada? (Kratom Guides)
  • FDA warns about possible contaminated herbal supplement parents may need to worry about (KUTV)
  • Where To Buy Kratom In New York And Is It Legal? (Kratom Guides)
  • What Are The Best Kratom Strains For Pain? (Kratom Guides)
  • Top Extracts Botanicals Review – The Best Vendor To Buy Kratom Online (Kratom Guides)
  • What Is The Legal Status of Kratom In Tennessee? (Kratom Guides)
  • Companies Leading In Selling Kratom And CBD/Hemp Products Online (Kratom Guides)
  • Is Kratom Legal In Florida In 2018 (Kratom Guides)

Miscellaneous Psychedelics/Psychoactives/Drug Policy

  • Psychedelic drug use associated with reduced partner violence in men (EurekAlert!)
  • FDA Monitors Social Media for Drug Abuse Trends (Pain News Network)
  • Michael Pollan Drops Acid — and Comes Back From His Trip Convinced (The New York Times)
  • How should we be teaching students about drugs? (Psymposia)
  • Rhode Island Wants to Treat Drug Dealers Like Murderers (Reason)
  • With The Rise Of Legal Weed, Drug Education Moves From 'Don't' to 'Delay' (NPR)
  • Bangladesh accused of using drugs war to hide political assassinations (The Telegraph)
  • The Feds Are Raiding the Offices of Doctors Who Prescribe Addiction Medication (Tonic)
  • Festival drug-testing shows a way to reduce harm (The Economist)
  • How psychedelic drugs made a comeback (DailyO)
  • A debate over plant consciousness is forcing us to confront the limitations of the human mind (Quartz)
  • Bestival to offer drug testing facilities for first time in bid to prevent more drug-related deaths (The Independent)
  • The Stigma Surrounding Hallucinogens Took Root in Western Colonialism (71 Republic)
  • Michael Pollan & the Objectification of the Psychedelic Experience (Disinfo)
  • Manchester's night-time adviser backs drug testers for festivals and clubs (The Guardian)
  • On Religious Sacraments: Holy Crackers and 'Evil Drugs' (Andrew Joseph)
  • Renewed interest in psychedelics as potentially useful therapeutic agents (Drug and Alcohol Research Connections)
  • We've been fighting the drug war for 50 years. So why aren't we winning? (The Appeal)
  • The Myth of People Who “Don’t Use Drugs” (Psychedelic Heaven)
  • About Me: Lawyer, Writer, Psychedelic Enthusiast (Andrew Joseph)
  • Psychedelics and Personality (ACS Publications)
  • The UK’s Cruel Drug Laws Ruin Lives, Including My Son’s (Talking Drugs)

Disclaimer: "This Week in Psychedelics" does not censor or analyze the news links presented here. The purpose of this column is solely to catalogue how psychedelics are presented by the mass media, which includes everything from the latest scientific research to misinformation.

Image by Dahtamnay, courtesy of Creative Commons licensing.

China's All-Seeing Credit Score System

Charles Rollet, writing for WIRED:

In the UK, credit scores are mostly used to determine whether people can get a credit card or loan. But in China, the government is developing a much broader “social credit” system partly based on people’s routine behaviours with the ultimate goal of determining the “trustworthiness” of the country’s 1.4 billion citizens.

It might sound like a futuristic dystopian nightmare but the system is already a reality. Social credit is preventing people from buying airline and train tickets, stopping social gatherings from happening, and blocking people from going on certain dating websites. Meanwhile, those viewed kindly are rewarded with discounted energy bills and similar perks.

China is going full-blown Black Mirror with its social credit system. It's pretty fucked up to outright ban people from buying airline and train tickets due to unpaid debts or prevent them from getting loans because they cheat in a video game.


Book Review - Dreamland

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The United States of America is in the midst of a widespread opiate epidemic that has devastated hundreds of small rural towns and suburbs across the country. The captivating story of exactly how this came to be is expertly told in acclaimed journalist Sam Quinones' fantastic book, Dreamland: The True Tale of America's Opiate Epidemic, which was published in 2015.

In Dreamland, Quinones magnificently blends together two seemingly-independent narratives: the overly generous prescription of pain medications during the 1990s (including Purdue Pharma's ambitious campaign to aggressively market and sell OxyContin) and the unforeseen—and unprecedented—arrival of cheap, consistent, high quality black tar heroin from one small county in Mexico. According to Quinones, these developments joined forces in a dangerous synergy that ultimately resulted in America's modern-day opiate epidemic.

The book opens with a ridiculously thorough timeline that begins with the distillation of morphine in 1804, moves on to the invention of the hypodermic syringe in 1853 (did you know that the inventor's wife was the first to die of injected drug overdose?), glances at the release of OxyContin in 1996, and ends with the FDA's 2014 approval of Targiniq ER, which combined timed-release oxycodone with naloxone. This timeline, which provides plenty of insight into what went on in between those four events, sets the stage for the book's narrative and successfully primes the reader for the information that follows.

And the actual book doesn't disappoint, either—as the dust-jacket blurb states, it introduces "a memorable cast of characters—pharma pioneers, young Mexican entrepreneurs, narcotics investigators, survivors, and parents, and Quinones shows how these tales fit together." Sure enough, about midway through Dreamland, the reader begins to see the sophisticated web that was woven by several groups of people who were simply following the capitalist dream (operating in their own best interest in an attempt to make as much money as possible), and the once-hidden connections between the people and places involved become as clear as crystal.

When it comes down to it, Dreamland is the best book that I've read so far this year. The story is compelling and unfolds beautifully, in a masterful manner that constantly tempts the reader to read the next chapter. The level of detail that is crammed into each page is truly impressive, but never overwhelming. Simply put—I enjoyed every single word. The topic isn't necessarily the most popular (for the average reader), so I'm not sure that I would recommend this book to someone unless they're already interested in America's opiate epidemic. However, if you are at all intrigued by the topic, then I wholeheartedly recommend this book to you. It will likely take a while to read, because it is packed so densely, but it will be worth your investment of money, time, and energy. And I will keep an eye out for any future books and articles by Quinones, as his writing is an absolute joy to read.

5/5 stars. 385 pages.

Banner image by jplenio, courtesy of Creative Commons licensing.

Synthetic Weed Is Back

Christopher Moraff, writing for The Daily Beast:

In 2011 and 2012, faced with a spike in emergency room visits, the Drug Enforcement Administration banned a handful of the compounds. Chemists continued tweaking the drugs to skirt ever-evolving synthetic drug laws, but since peaking in 2015, calls to poison centers for synthetic marijuana dropped by more than half. But over the past year K2 has made a comeback; and a recent spate of poisonings has public health officials worried.

"Scary as hell" is right. Crazy to think that although synthetic cannabinoids were relatively unpopular the past few years, they really do seem to be experiencing a full-fledged comeback now—especially among opioid users.